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Cafestol is known to increase Serum cholesterol level. Yet, it is unclear whether this has a negative impact on the heart health.

Coffee and Health: A Review of Recent Human Research (2007): "The results of epidemiological research suggest that coffee consumption may help prevent several chronic diseases, including type 2 diabetes mellitus, Parkinson's disease and liver disease (cirrhosis and hepatocellular carcinoma). Most prospective cohort studies have not found coffee consumption to be associated with significantly increased cardiovascular disease risk."
Coffee consumption and risk of coronary heart diseases: A meta-analysis of 21 prospective cohort studies (2009): A meta analysis of 21 cohort studies. moderate coffee consumption -> significantly lower CHD (coronary heart disease)
Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis: "The present meta-analysis of prospective cohort studies indicated that light to moderate coffee intake is associated with a reduced risk of death from all causes, particularly in women."
Coffee Consumption and Cardiovascular Diseases – Has the Time Come to Change Dietary Advice? A Mini Review (2016): "The reports on a possible correlation between coffee drinking and heart diseases have also generated optimistic results. No adverse associations between coffee consumption and coronary heart disease, stroke, and hypertension have been found. What is more, some authors demonstrated that coffee drinking may prevent cardiovascular diseases."